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Step by Step

Getting started on XOLAIR is a little different from other medications. Once your doctor gives you your prescription, there are a few steps that take place before you get your first treatment. In most cases, these steps take about 2 weeks.

Take the guided tour

The steps below show you what may lie ahead if your doctor prescribes XOLAIR.

Financial support options include a $5 co-pay for XOLAIR

See if you qualify for a $5 co-pay with the XOLAIR Co-pay Card Program, and find out about other Patient Assistance Programs.



Learn more

Your Doctor Prescribes XOLAIR

Once your doctor prescribes XOLAIR, you must complete the Patient Authorization and Notice of Release of Information (PAN) form when seeking help from XOLAIR Access Solutions.*

  • YOU sign and date the PAN form.
    Signing the PAN form is important so your health plan's coverage can be verified.

*XOLAIR Access Solutions is a program to help patients whose plans don't pay for XOLAIR. XOLAIR Access Solutions can also help patients who have concerns about their co-pay. For more information, go to or call (800) 704-6610.

Checking Coverage

XOLAIR Access Solutions, your specialty pharmacy or your doctor's office will find out if your health plan covers XOLAIR.

  • YOU can expect your doctor's office to work with XOLAIR Access Solutions or a specialty pharmacy to check if your health plan covers the costs for XOLAIR and if a pre-approval is needed.

A specialty pharmacy is a type of pharmacy with expertise in certain medical conditions and injectable medications like XOLAIR.

Verifying Information

XOLAIR Access Solutions or the specialty pharmacy calls you to verify your information and lets you know if you have a co-pay for XOLAIR.

  • YOU should share any concerns about paying for XOLAIR and ask if you qualify for co-pay assistance, which may lower your medication costs.
  • YOU should always return phone calls from the specialty pharmacy so they have all the information they need.
  • YOU should be aware the specialty pharmacy may not mention XOLAIR in a message, due to privacy laws.

Shipping XOLAIR

Once you pay your co-pay, the specialty pharmacy ships XOLAIR to the place you will be treated. You will get a call to schedule an appointment for your treatment.

  • YOU tell the specialty pharmacy where you will be treated. Remember to show up for your appointment.

Please note: Your XOLAIR might not come from a specialty pharmacy. Instead, your doctor may buy XOLAIR and get paid by your health plan for the cost of the medicine. This is called "buy and bill."

Locate a doctor near you

An important part of getting diagnosed and treated for CIU is finding a doctor who can help. Find a specialist near you by city or zip code.



Use the Physician Locator

What is XOLAIR?

XOLAIR® (omalizumab) for subcutaneous use is an injectable prescription medicine used to treat adults and children 12 years of age and older with chronic idiopathic urticaria (CIU; chronic hives without a known cause) who continue to have hives that are not controlled by H1 antihistamine treatment.

XOLAIR is not used to treat other forms of urticaria.


What is the most important information I should know about XOLAIR?

Severe allergic reaction. A severe allergic reaction called anaphylaxis can happen when you receive XOLAIR. The reaction can occur after the first dose, or after many doses. It may also occur right after a XOLAIR injection or days later. Anaphylaxis is a life-threatening condition and can lead to death. Go to the nearest emergency room right away if you have any of these symptoms of an allergic reaction:

  • wheezing, shortness of breath, cough, chest tightness, or trouble breathing
  • low blood pressure, dizziness, fainting, rapid or weak heartbeat, anxiety, or feeling of "impending doom"
  • flushing, itching, hives, or feeling warm
  • swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing

Your healthcare provider will monitor you closely for symptoms of an allergic reaction while you are receiving XOLAIR and for a period of time after your injection. Your healthcare provider should talk to you about getting medical treatment if you have symptoms of an allergic reaction after leaving the healthcare provider's office or treatment center.

Do not receive XOLAIR if you are allergic to omalizumab or any of the ingredients in XOLAIR.

Before receiving XOLAIR, tell your healthcare provider about all of your medical conditions, including if you:

  • have ever had a severe allergic reaction called anaphylaxis
  • have or have had a parasitic infection
  • have or have had cancer
  • are pregnant or plan to become pregnant. It is not known if XOLAIR may harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if XOLAIR passes into your breast milk. Talk with your healthcare provider about the best way to feed your baby while you receive XOLAIR.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, or herbal supplements.

How should I receive XOLAIR?

  • XOLAIR should be given by your healthcare provider, in a healthcare setting.
  • XOLAIR is given in 1 or more injections under the skin (subcutaneous), 1 time every 4 weeks.
  • In patients with chronic hives, a blood test is not necessary to determine the dose or dosing frequency.
  • Do not decrease or stop taking any of your other hive medicine unless your healthcare providers tell you to.
  • You may not see improvement in your symptoms right away after XOLAIR treatment.

What are the possible side effects of XOLAIR?
XOLAIR may cause serious side effects, including:

  • See, "What is the most important information I should know about XOLAIR" regarding the risk of anaphylaxis.
  • Cancer. Cases of cancer were observed in some people who received XOLAIR.
  • Fever, muscle aches, and rash. Some people who take XOLAIR get these symptoms 1 to 5 days after receiving a XOLAIR injection. If you have any of these symptoms, tell your healthcare provider.
  • Parasitic infection. Some people who are at a high risk for parasite (worm) infections, get a parasite infection after receiving XOLAIR. Your healthcare provider can test your stool to check if you have a parasite infection.
  • Heart and circulation problems. Some people who receive XOLAIR have had chest pain, heart attack, blood clots in the lungs or legs, or temporary symptoms of weakness on one side of the body, slurred speech, or altered vision. It is not known whether this is caused by XOLAIR.

The most common side effects of XOLAIR:

  • In people with chronic idiopathic urticaria: nausea, headaches, swelling of the inside of your nose, throat or sinuses, cough, joint pain, and upper respiratory tract infection.

These are not all the possible side effects of XOLAIR. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at (800) FDA-1088 or You may also report side effects to Genentech at (888) 835-2555 or Novartis Pharmaceuticals Corporation at 888-669-6682.

Please see full Prescribing Information, including Medication Guide for additional Important Safety Information.

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