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Your XOLAIR Treatment Routine

What happens once you start XOLAIR treatment? Where do you go for injections? You may have several questions about what your XOLAIR journey will be. This is normal. Especially since you may not have been treated with XOLAIR before.

Start getting answers to your questions using the information below.

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Going for your XOLAIR injections

You will need to go for your XOLAIR injections every 4 weeks. You may get 1 or 2 injections per visit, determined by your doctor. If he or she doesn't give XOLAIR injections, the doctor's office may help you find an injection center close by. Just remember to keep your appointments as scheduled. Also, be sure to read the XOLAIR Medication Guide before each injection.

After your injection

After your XOLAIR injection, you'll stay in the doctor's office for some time so he or she can watch you for signs or symptoms of a severe allergic reaction called anaphylaxis. Signs and symptoms of anaphylaxis include:

  • wheezing, shortness of breath, cough, chest tightness, or trouble breathing
  • low blood pressure, dizziness, fainting, rapid or weak heartbeat, anxiety, or feeling of "impending doom"
  • flushing, itching, hives, or feeling warm
  • swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing

If you have signs or symptoms of anaphylaxis, tell your doctor right away.

Starting on XOLAIR

Here are a few thoughts to keep in mind once you get started on XOLAIR:

  • You may not see improvement right after starting your XOLAIR treatment. Remember that results may vary.
  • Be sure to follow your doctor's instructions about taking XOLAIR. You can also talk to your doctor about when you might expect to see results.

How to tell if XOLAIR is working

You may have less itching and fewer hives once your XOLAIR treatment starts working. It's important to stick with your treatment as prescribed by your doctor.

What else should I know about XOLAIR?

You should know the XOLAIR Indication and Important Safety Information.

  • You should not receive XOLAIR if you have ever had an allergic reaction to a XOLAIR injection.
  • Do not change or stop taking any of your other CIU medicines unless your healthcare provider tells you to do so.
  • If you have any questions, talk to your doctor for more information or call 1-866-4- XOLAIR (1-866-496-5247).
  • You may report side effects to the FDA at 1-800-FDA-1088.

Staying on XOLAIR

Only your doctor can tell you how long you'll need to take XOLAIR. He or she will assess from time to time if you need to continue treatment. Just remember, XOLAIR is not a cure for chronic idiopathic urticaria (CIU). Do not change or stop taking any of your CIU medicines unless your doctor tells you to.

What is XOLAIR?

XOLAIR® (omalizumab) for subcutaneous use is an injectable prescription medicine used to treat adults and children 12 years of age and older with chronic idiopathic urticaria (CIU; chronic hives without a known cause) who continue to have hives that are not controlled by H1 antihistamine treatment.

XOLAIR is not used to treat other forms of urticaria.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about XOLAIR?

Severe allergic reaction. A severe allergic reaction called anaphylaxis can happen when you receive XOLAIR. The reaction can occur after the first dose, or after many doses. It may also occur right after a XOLAIR injection or days later. Anaphylaxis is a life-threatening condition and can lead to death. Go to the nearest emergency room right away if you have any of these symptoms of an allergic reaction:

  • wheezing, shortness of breath, cough, chest tightness, or trouble breathing
  • low blood pressure, dizziness, fainting, rapid or weak heartbeat, anxiety, or feeling of "impending doom"
  • flushing, itching, hives, or feeling warm
  • swelling of the throat or tongue, throat tightness, hoarse voice, or trouble swallowing

Your healthcare provider will monitor you closely for symptoms of an allergic reaction while you are receiving XOLAIR and for a period of time after your injection. Your healthcare provider should talk to you about getting medical treatment if you have symptoms of an allergic reaction after leaving the healthcare provider's office or treatment center.

Do not receive XOLAIR if you are allergic to omalizumab or any of the ingredients in XOLAIR.

Before receiving XOLAIR, tell your healthcare provider about all of your medical conditions, including if you:

  • have ever had a severe allergic reaction called anaphylaxis
  • have or have had a parasitic infection
  • have or have had cancer
  • are pregnant or plan to become pregnant. It is not known if XOLAIR may harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if XOLAIR passes into your breast milk. Talk with your healthcare provider about the best way to feed your baby while you receive XOLAIR.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, or herbal supplements.

How should I receive XOLAIR?

  • XOLAIR should be given by your healthcare provider, in a healthcare setting.
  • XOLAIR is given in 1 or more injections under the skin (subcutaneous), 1 time every 4 weeks.
  • In patients with chronic hives, a blood test is not necessary to determine the dose or dosing frequency.
  • Do not decrease or stop taking any of your other hive medicine unless your healthcare providers tell you to.
  • You may not see improvement in your symptoms right away after XOLAIR treatment.

What are the possible side effects of XOLAIR?
XOLAIR may cause serious side effects, including:

  • See, "What is the most important information I should know about XOLAIR" regarding the risk of anaphylaxis.
  • Cancer. Cases of cancer were observed in some people who received XOLAIR.
  • Fever, muscle aches, and rash. Some people who take XOLAIR get these symptoms 1 to 5 days after receiving a XOLAIR injection. If you have any of these symptoms, tell your healthcare provider.
  • Parasitic infection. Some people who are at a high risk for parasite (worm) infections, get a parasite infection after receiving XOLAIR. Your healthcare provider can test your stool to check if you have a parasite infection.
  • Heart and circulation problems. Some people who receive XOLAIR have had chest pain, heart attack, blood clots in the lungs or legs, or temporary symptoms of weakness on one side of the body, slurred speech, or altered vision. It is not known whether this is caused by XOLAIR.

The most common side effects of XOLAIR:

  • In people with chronic idiopathic urticaria: nausea, headaches, swelling of the inside of your nose, throat or sinuses, cough, joint pain, and upper respiratory tract infection.

These are not all the possible side effects of XOLAIR. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555 or Novartis Pharmaceuticals Corporation at 888-669-6682.

Please see full Prescribing Information, including Medication Guide for additional Important Safety Information.

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