How XOLAIR (Omalizumab) May Work

How XOLAIR May Work in CIU

To understand how XOLAIR may work in helping to reduce itch severity and number of hives in appropriate CIU patients, you should know about mast cells, histamine, and immunoglobulin E (IgE).

Mast cells are cells found in almost all tissues of the body, such as skin. They play an important role in CIU by releasing certain inflammatory substances.
Histamine is a chemical in the body that causes inflammation, leading to hives and itching associated with CIU.
IgE is a substance made by the body that attaches to receptors on mast cells, triggering them to release histamine and other inflammatory substances under certain conditions.

How XOLAIR (Omalizumab) May Treat Chronic Idiopathic Urticaria (CIU)

Even though medical experts don’t exactly know how XOLAIR improves the symptoms of CIU, you can see that XOLAIR helped people with itch and hive symptoms in the clinical study results.