About the XOLAIR autoinjector

• The XOLAIR autoinjector comes boxed
• DO NOT OPEN the carton until you are ready to use this medicine
• Do not use if the packaging is damaged or appears to be tampered with as it may not be safe for you to use. Call your doctor’s office for guidance. For additional information, call 1-866-4XOLAIR (1-866-496-5247)
• The boxed XOLAIR autoinjector should be stored in the refrigerator. Always make sure XOLAIR is kept at the correct temperature (between 36 °F and 46 °F)

1. Take the carton containing the XOLAIR autoinjector out of the refrigerator.
   • If your dose requires you to give more than 1 injection, take all cartons out of the refrigerator at the same time. The following steps must be followed for each autoinjector
2. Check the expiration date on the XOLAIR carton.
   • Do not use if the expiration date has passed. If the expiration date has passed, safely throw away the XOLAIR autoinjector in a sharps disposal container and contact your healthcare provider
3. Place the carton on a clean, flat surface.
   • Set aside the carton for at least 30 to 45 minutes so the XOLAIR autoinjector can warm up on its own to room temperature. Leave the XOLAIR autoinjector in the carton to protect it from light
   • If the XOLAIR autoinjector does not reach room temperature, this could cause the injection to feel uncomfortable
   • Do not speed up the warming process using any heat sources such as warm water or a microwave
4. Open the carton.
   • Wash your hands with soap and water
   • Take the autoinjector out of the carton
   • Check the expiration date on the autoinjector
   • Do not use it if the expiration date has passed. If the expiration date has passed, safely throw away the XOLAIR autoinjector in a sharps disposal container and contact your healthcare provider
   • Do not turn the carton upside down to take out the autoinjector, as this may damage the autoinjector
   • Do not hold the autoinjector by the cap. Make sure you hold the autoinjector by the middle
   • Do not remove the cap until you are ready to inject
5. Inspect the XOLAIR autoinjector closely.
   • Check the autoinjector. The medicine in the autoinjector should be clear and colorless to pale brownish-yellow. Do not use the autoinjector if the medicine contains particles or is cloudy or brown
6. Choose an injection site.
7. Wipe the injection site with an alcohol swab in a circular motion and let it air-dry for 10 seconds.
   • Do not fan or blow on the cleaned skin
   • Do not touch the injection site again before giving the injection

1. Hold the XOLAIR autoinjector firmly with 1 hand and pull the cap straight off with your other hand.
   • Do not twist the cap
   • Do not put the cap back on the XOLAIR autoinjector. Throw away the cap in the regular household trash
   • Do not clean or touch the needle guard of the device
2. Hold the XOLAIR autoinjector comfortably with the needle guard directly against the skin.
   • The XOLAIR autoinjector should be at a 90-degree angle against the skin

• Press straight down and hold the XOLAIR autoinjector firmly against the skin. The first click indicates that the injection has started
• Hold the XOLAIR autoinjector tightly in place. Do not change the angle of injection or remove the autoinjector until the injection is completed
• Keep holding the autoinjector against the skin. The green indicator will move within the viewing window
• Listen for the second click. This indicates that the injection is almost complete
• Hold the XOLAIR autoinjector in position until the green indicator has stopped moving and completely fills the viewing window to make sure the injection is complete

1. There may be a little bleeding at the injection site. You can press a cotton ball or gauze over the injection site.
   • Do not rub the injection site
   • If needed, cover the injection site with a small bandage
   • In case of skin contact with the medicine, wash the area that touched the medicine with water    
2. If your prescribed dose requires more than 1 injection:
   • Throw away the used XOLAIR autoinjector as described in “Disposing of the autoinjector” below
   • Repeat the steps in “Preparing for the injection,” “Giving the injection,” and “Start the injection” for the next injection using a new autoinjector
   • Choose a different injection site for each new injection—at least 1 inch from other injection sites
   • Complete all the required injections for your prescribed dose, immediately one after another. Contact your healthcare provider if you have any questions

Throw away (dispose of) your used XOLAIR autoinjectors in an FDA-cleared sharps disposal container right away after use.

• The XOLAIR autoinjector is a single-dose autoinjector and should not be used again
• Do not throw away XOLAIR autoinjectors in your household trash
• Do not recap the XOLAIR autoinjector

If you do not have an FDA-cleared sharps disposal container, you may use a household container that is:

• Made of a heavy-duty, leak-resistant plastic
• Can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out
• Upright and stable during use
• Properly labeled: Hazardous waste inside the container

You should reach out to your pharmacy for a sharps disposal container. All pharmacies have different processes.

What to do when your sharps container is full:

• Follow your community guidelines for the right way to dispose of your sharps disposal container
• There may be state or local laws about how you should throw away used XOLAIR autoinjectors

For more information about safe sharps disposal, and for specific information about sharps disposal in the state you live in, go to the FDA website at: http://www.fda.gov/safesharpsdisposal.

IMPORTANT: Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.